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Leveraging Polygenic Functional Enrichment to Improve GWAS Power
Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a method that leverages polygenic functional enrichment to incorporate coding, conserved, regulatory, and LD-related genomic annotations into...
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| Izdano u: | Am J Hum Genet |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6323418/ https://ncbi.nlm.nih.gov/pubmed/30595370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2018.11.008 |
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