Wird geladen...

Leveraging Polygenic Functional Enrichment to Improve GWAS Power

Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a method that leverages polygenic functional enrichment to incorporate coding, conserved, regulatory, and LD-related genomic annotations into...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Am J Hum Genet
Hauptverfasser: Kichaev, Gleb, Bhatia, Gaurav, Loh, Po-Ru, Gazal, Steven, Burch, Kathryn, Freund, Malika K., Schoech, Armin, Pasaniuc, Bogdan, Price, Alkes L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323418/
https://ncbi.nlm.nih.gov/pubmed/30595370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2018.11.008
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!