Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data

Despite strong transethnic genetic correlations reported in the literature for many complex traits, the non-transferability of polygenic risk scores across populations suggests the presence of population-specific components of genetic architecture. We propose an approach that models GWAS summary dat...

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Pubblicato in:Am J Hum Genet
Autori principali: Shi, Huwenbo, Burch, Kathryn S., Johnson, Ruth, Freund, Malika K., Kichaev, Gleb, Mancuso, Nicholas, Manuel, Astrid M., Dong, Natalie, Pasaniuc, Bogdan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7273527/
https://ncbi.nlm.nih.gov/pubmed/32442408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.04.012
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