Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data

Despite strong transethnic genetic correlations reported in the literature for many complex traits, the non-transferability of polygenic risk scores across populations suggests the presence of population-specific components of genetic architecture. We propose an approach that models GWAS summary dat...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Am J Hum Genet
Главные авторы: Shi, Huwenbo, Burch, Kathryn S., Johnson, Ruth, Freund, Malika K., Kichaev, Gleb, Mancuso, Nicholas, Manuel, Astrid M., Dong, Natalie, Pasaniuc, Bogdan
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2020
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7273527/
https://ncbi.nlm.nih.gov/pubmed/32442408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.04.012
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы