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Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits

Although genome-wide association studies (GWASs) have identified thousands of risk loci for many complex traits and diseases, the causal variants and genes at these loci remain largely unknown. Here, we introduce a method for estimating the local genetic correlation between gene expression and a com...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Mancuso, Nicholas, Shi, Huwenbo, Goddard, Pagé, Kichaev, Gleb, Gusev, Alexander, Pasaniuc, Bogdan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339290/
https://ncbi.nlm.nih.gov/pubmed/28238358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.01.031
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