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Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity. The phenothiazine mepazine has been shown to inhibit the proteolytic activity of MALT1 and is frequently used to...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Meloni, Laura, Verstrepen, Lynn, Kreike, Marja, Staal, Jens, Driege, Yasmine, Afonina, Inna S., Beyaert, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320945/
https://ncbi.nlm.nih.gov/pubmed/30513612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23123144
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