The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model

Recent clinical studies have demonstrated the protective effect of xanthine oxidase (XO) inhibitors against chronic kidney diseases, although the underlying molecular mechanisms remain unclear. However, to date, neither clinical nor basic research has been carried out to elucidate the efficacy of XO...

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Publié dans:Int J Mol Sci
Auteurs principaux: Inoue, Masa-Ki, Yamamotoya, Takeshi, Nakatsu, Yusuke, Ueda, Koji, Inoue, Yuki, Matsunaga, Yasuka, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Morii, Kenichi, Sasaki, Kensuke, Masaki, Takao, Suzuki, Yusuke, Asano, Tomoichiro, Kushiyama, Akifumi
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320819/
https://ncbi.nlm.nih.gov/pubmed/30544662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19123967
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