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Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2
Prostaglandin E2 (PGE(2)) via its Gα(s)-coupled EP2 receptor protects cerebral cortical neurons from excitotoxic and anoxic injury, though EP2 receptor activation can also cause secondary neurotoxicity in chronic inflammation. We performed a high-throughput screen of a library of 292 000 small molec...
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| Veröffentlicht in: | ACS Chem Neurosci |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6318807/ https://ncbi.nlm.nih.gov/pubmed/29292987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00486 |
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