Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

Activation of the Gαs-coupled EP2 receptor for prostaglandin E2 (PGE(2)) promotes cell survival in several models of tissue damage. To advance understanding of EP2 functions, we designed experiments to develop allosteric potentiators of this key prostaglandin receptor. Screens of 292,000 compounds i...

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Detalhes bibliográficos
Main Authors: Jiang, Jianxiong, Ganesh, Thota, Du, Yuhong, Thepchatri, Pahk, Rojas, Asheebo, Lewis, Iestyn, Kurtkaya, Serdar, Li, Lian, Qui, Min, Serrano, Geidy, Shaw, Renee, Sun, Aiming, Dingledine, Ray
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836658/
https://ncbi.nlm.nih.gov/pubmed/20080612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909310107
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