Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

Activation of the Gαs-coupled EP2 receptor for prostaglandin E2 (PGE(2)) promotes cell survival in several models of tissue damage. To advance understanding of EP2 functions, we designed experiments to develop allosteric potentiators of this key prostaglandin receptor. Screens of 292,000 compounds i...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jiang, Jianxiong, Ganesh, Thota, Du, Yuhong, Thepchatri, Pahk, Rojas, Asheebo, Lewis, Iestyn, Kurtkaya, Serdar, Li, Lian, Qui, Min, Serrano, Geidy, Shaw, Renee, Sun, Aiming, Dingledine, Ray
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2010
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836658/
https://ncbi.nlm.nih.gov/pubmed/20080612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909310107
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