Diaryl Hydroxylamines as Pan or Dual Inhibitors of Indoleamine 2,3-Dioxygenase-1, Indoleamine 2,3-Dioxygenase-2 and Tryptophan Dioxygenase

Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the c...

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Détails bibliographiques
Publié dans:Eur J Med Chem
Auteurs principaux: Winters, Maria, DuHadaway, James B., Pham, Khoa N., Lewis-Ballester, Ariel, Badir, Shorouk, Wai, Jenny, Sheikh, Eesha, Yeh, Syun-Ru, Prendergast, George C., Muller, Alexander J., Malachowski, William P.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318801/
https://ncbi.nlm.nih.gov/pubmed/30469041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.11.010
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