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Structure-Activity Study of Brassinin Derivatives as Indoleamine 2,3-Dioxygenase Inhibitors

A screen of indole-based structures revealed the natural product brassinin to be a moderate inhibitor of indoleamine 2,3-dioxygenase (IDO), a new cancer immunosuppression target. A structure-activity study was undertaken to determine which elements of the brassinin structure could be modified to enh...

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Autors principals: Gaspari, Paul, Banerjee, Tinku, Malachowski, William P., Muller, Alexander J., Prendergast, George C., DuHadaway, James, Bennett, Shauna, Donovan, Ashley M.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527235/
https://ncbi.nlm.nih.gov/pubmed/16420054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0508888
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