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Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer
The tryptophan catabolic enzyme indoleamine 2,3-dioxygenase-1 (IDO1) has attracted enormous attention in driving cancer immunosuppression, neovascularization and metastasis. IDO1 suppresses local CD8+ T effector cells and natural killer cells and induces CD4+ T regulatory cells (iTreg) and myeloid-d...
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| Publicado no: | Int Rev Cell Mol Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6054468/ https://ncbi.nlm.nih.gov/pubmed/29413890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.ircmb.2017.07.004 |
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