Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer

The tryptophan catabolic enzyme indoleamine 2,3-dioxygenase-1 (IDO1) has attracted enormous attention in driving cancer immunosuppression, neovascularization and metastasis. IDO1 suppresses local CD8+ T effector cells and natural killer cells and induces CD4+ T regulatory cells (iTreg) and myeloid-d...

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Detaylı Bibliyografya
Yayımlandı:Int Rev Cell Mol Biol
Asıl Yazarlar: Prendergast, George C., Malachowski, William J., Mondal, Arpita, Scherle, Peggy, Muller, Alexander J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054468/
https://ncbi.nlm.nih.gov/pubmed/29413890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.ircmb.2017.07.004
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