Therapeutic Antibody Targeting of Indoleamine-2,3-Dioxygenase (IDO2) Inhibits Autoimmune Arthritis

Rheumatoid arthritis (RA) is a debilitating inflammatory autoimmune disease with no known cure. Recently, we identified the immunomodulatory enzyme indoleamine-2,3-dioxygenase 2 (IDO2) as an essential mediator of autoreactive B and T cell responses driving RA. However, therapeutically targeting IDO2...

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Bibliografiske detaljer
Udgivet i:Clin Immunol
Main Authors: Merlo, Lauren M.F., Grabler, Samantha, DuHadaway, James B., Pigott, Elizabeth, Manley, Kaylend, Prendergast, George C., Laury-Kleintop, Lisa D., Mandik-Nayak, Laura
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466478/
https://ncbi.nlm.nih.gov/pubmed/28223071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2017.01.016
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