Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer

Genetic and pharmacological studies of indoleamine 2,3-dioxygenase (IDO) have established this tryptophan catabolic enzyme as a central driver of malignant development and progression. IDO acts in tumor, stromal and immune cells to support pathogenic inflammatory processes that engender immune toler...

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Bibliographic Details
Published in:Cancer Immunol Immunother
Main Authors: Prendergast, George C., Smith, Courtney, Thomas, Sunil, Mandik-Nayak, Laura, Laury-Kleintop, Lisa, Metz, Richard, Muller, Alexander J.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2014
Subjects:
Focussed Research Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384696/
https://ncbi.nlm.nih.gov/pubmed/24711084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-014-1549-4
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