TIGAR knockdown enhanced the anticancer effect of aescin via regulating autophagy and apoptosis in colorectal cancer cells

Our previous study showed that TP53-induced glycolysis and apoptosis regulator (TIGAR) regulated ROS, autophagy, and apoptosis in response to hypoxia and chemotherapeutic drugs. Aescin, a triterpene saponin, exerts anticancer effects and increases ROS levels. The ROS is a key upstream signaling to a...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Li, Bin, Wang, Zhong, Xie, Jia-ming, Wang, Gang, Qian, Li-qiang, Guan, Xue-mei, Shen, Xue-ping, Qin, Zheng-hong, Shen, Gen-hai, Li, Xiao-qiang, Gao, Quan-gen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318299/
https://ncbi.nlm.nih.gov/pubmed/29769743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0001-2
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