Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells

Decitabine (DAC) is a well-known DNA methyltransferase inhibitor, which has been widely used for the treatment of acute myeloid leukemia (AML). However, in addition to hypomethylation, DAC in AML is also involved in cell metabolism, apoptosis, and immunity. The TP53-induced glycolysis and apoptosis...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Li, Lanzhu, Liu, Wenjie, Sun, Qian, Zhu, Han, Hong, Ming, Qian, Sixuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836025/
https://ncbi.nlm.nih.gov/pubmed/33532040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8877460
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