Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells

Decitabine (DAC) is a well-known DNA methyltransferase inhibitor, which has been widely used for the treatment of acute myeloid leukemia (AML). However, in addition to hypomethylation, DAC in AML is also involved in cell metabolism, apoptosis, and immunity. The TP53-induced glycolysis and apoptosis...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Li, Lanzhu, Liu, Wenjie, Sun, Qian, Zhu, Han, Hong, Ming, Qian, Sixuan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836025/
https://ncbi.nlm.nih.gov/pubmed/33532040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8877460
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