Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy

Aescin, a natural mixture of triterpene saponins, has been reported to exert anticancer effect. Recent studies show that aescin increases intracellular reactive oxygen species (ROS) levels. However, whether the increased ROS play a role in the anticancer action of aescin remains to be explored. In t...

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Foilsithe in:Acta Pharmacol Sin
Main Authors: Li, Bin, Wu, Guo-liang, Dai, Wei, Wang, Gang, Su, Hao-yuan, Shen, Xue-ping, Zhan, Rui, Xie, Jia-ming, Wang, Zhong, Qin, Zheng-hong, Gao, Quan-gen, Shen, Gen-hai
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289397/
https://ncbi.nlm.nih.gov/pubmed/29921885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0047-1
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