Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment

The second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) stimulates gene expression via the cAMP-regulated transcriptional coactivator (CRTC) family of cAMP response element-binding protein coactivators. In the basal state, CRTCs are phosphorylated by salt-inducible kinases (SIKs) and seques...

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Publicado en:iScience
Main Authors: Sonntag, Tim, Ostojić, Jelena, Vaughan, Joan M., Moresco, James J., Yoon, Young-Sil, Yates, John R., Montminy, Marc
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317279/
https://ncbi.nlm.nih.gov/pubmed/30611118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.12.012
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