Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms. However, the factors driving subcellular drug distribution are complex and poorly understood. Here, we describe for the fir...

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Dettagli Bibliografici
Pubblicato in:Cells
Autori principali: Englinger, Bernhard, Kallus, Sebastian, Senkiv, Julia, Laemmerer, Anna, Moser, Patrick, Gabler, Lisa, Groza, Diana, Kowol, Christian R., Heffeter, Petra, Grusch, Michael, Berger, Walter
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
Soggetti:
Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315953/
https://ncbi.nlm.nih.gov/pubmed/30544798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7120259
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