Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms. However, the factors driving subcellular drug distribution are complex and poorly understood. Here, we describe for the fir...

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Dades bibliogràfiques
Publicat a:Cells
Autors principals: Englinger, Bernhard, Kallus, Sebastian, Senkiv, Julia, Laemmerer, Anna, Moser, Patrick, Gabler, Lisa, Groza, Diana, Kowol, Christian R., Heffeter, Petra, Grusch, Michael, Berger, Walter
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
Matèries:
Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315953/
https://ncbi.nlm.nih.gov/pubmed/30544798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7120259
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