Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms. However, the factors driving subcellular drug distribution are complex and poorly understood. Here, we describe for the fir...

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Bibliographic Details
Published in:Cells
Main Authors: Englinger, Bernhard, Kallus, Sebastian, Senkiv, Julia, Laemmerer, Anna, Moser, Patrick, Gabler, Lisa, Groza, Diana, Kowol, Christian R., Heffeter, Petra, Grusch, Michael, Berger, Walter
Format: Artigo
Language:Inglês
Published: MDPI 2018
Subjects:
Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315953/
https://ncbi.nlm.nih.gov/pubmed/30544798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7120259
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