Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms. However, the factors driving subcellular drug distribution are complex and poorly understood. Here, we describe for the fir...

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Vydáno v:Cells
Hlavní autoři: Englinger, Bernhard, Kallus, Sebastian, Senkiv, Julia, Laemmerer, Anna, Moser, Patrick, Gabler, Lisa, Groza, Diana, Kowol, Christian R., Heffeter, Petra, Grusch, Michael, Berger, Walter
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
Témata:
Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315953/
https://ncbi.nlm.nih.gov/pubmed/30544798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7120259
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