RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including invariant natural killer T (iNKT) and γδ-T cells, bu...

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Publicado no:Nat Commun
Main Authors: Venken, Koen, Jacques, Peggy, Mortier, Céline, Labadia, Mark E., Decruy, Tine, Coudenys, Julie, Hoyt, Kathleen, Wayne, Anita L., Hughes, Robert, Turner, Michael, Van Gassen, Sofie, Martens, Liesbet, Smith, Dustin, Harcken, Christian, Wahle, Joseph, Wang, Chao-Ting, Verheugen, Eveline, Schryvers, Nadia, Varkas, Gaëlle, Cypers, Heleen, Wittoek, Ruth, Piette, Yves, Gyselbrecht, Lieve, Van Calenbergh, Serge, Van den Bosch, Filip, Saeys, Yvan, Nabozny, Gerald, Elewaut, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315029/
https://ncbi.nlm.nih.gov/pubmed/30602780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07911-6
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