Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

Invariant natural killer T (iNKT) cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. Here, we report the structure and function of a novel class of aromatic α-galactosylceramide structurally related glycolipids with marked...

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Autori principali: Aspeslagh, Sandrine, Li, Yali, Yu, Esther Dawen, Pauwels, Nora, Trappeniers, Matthias, Girardi, Enrico, Decruy, Tine, Van Beneden, Katrien, Venken, Koen, Drennan, Michael, Leybaert, Luc, Wang, Jing, Franck, Richard W, Van Calenbergh, Serge, Zajonc, Dirk M, Elewaut, Dirk
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117654/
https://ncbi.nlm.nih.gov/pubmed/21552205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.145
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