Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Activated invariant natural killer T (iNKT) cells rapidly produce large amounts of cytokines, but how cytokine mRNAs are induced, stabilized and mobilized following iNKT activation is still unclear. Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), links...

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Publicado en:Nat Commun
Main Authors: Govindarajan, Srinath, Gaublomme, Djoere, Van der Cruyssen, Renée, Verheugen, Eveline, Van Gassen, Sofie, Saeys, Yvan, Tavernier, Simon, Iwawaki, Takao, Bloch, Yehudi, Savvides, Savvas. N., Lambrecht, Bart N., Janssens, Sophie, Elewaut, Dirk, Drennan, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297233/
https://ncbi.nlm.nih.gov/pubmed/30559399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07758-x
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