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A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model
BACKGROUND: We examined whether metoclopramide (MCP), a modulator of dopamine and serotonin receptors, alleviated colitis and had synergistic effects when coadministered with 5-aminosalicylic acid (5-ASA) in an experimental model of colitis. METHODS: MCP azo-linked to 5-ASA (5-[4-chloro-2-{2-(diethy...
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| Udgivet i: | Drug Des Devel Ther |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Dove Medical Press
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6312693/ https://ncbi.nlm.nih.gov/pubmed/30643389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S185257 |
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