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A Challenging Pie to Splice: Drugging the Spliceosome

Over the last decade, considerable effort has been directed at developing drugs that target the spliceosome. The resulting synthetic and natural product splice modulators have opened new avenues for the interrogation of disease-associated splicing events. In this Minireview, an overview is provided...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: León, Brian, Kashyap, Manoj K., Chan, Warren C., Krug, Kelsey A., Castro, Januario E., La Clair, James J., Burkart, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311392/
https://ncbi.nlm.nih.gov/pubmed/28371109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201701065
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