Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

RNA splicing plays a fundamental role in human biology. Its relevance in cancer is rapidly emerging as demonstrated by spliceosome mutations that determine the prognosis of patients with hematologic malignancies. We report studies using FD-895 and pladienolide-B in primary leukemia cells derived fro...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Haematologica
Prif Awduron: Kashyap, Manoj K., Kumar, Deepak, Villa, Reymundo, La Clair, James J., Benner, Chris, Sasik, Roman, Jones, Harrison, Ghia, Emanuela M., Rassenti, Laura Z., Kipps, Thomas J., Burkart, Michael D., Castro, Januario E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Ferrata Storti Foundation 2015
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486229/
https://ncbi.nlm.nih.gov/pubmed/25862704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.122069
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