Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

RNA splicing plays a fundamental role in human biology. Its relevance in cancer is rapidly emerging as demonstrated by spliceosome mutations that determine the prognosis of patients with hematologic malignancies. We report studies using FD-895 and pladienolide-B in primary leukemia cells derived fro...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Kashyap, Manoj K., Kumar, Deepak, Villa, Reymundo, La Clair, James J., Benner, Chris, Sasik, Roman, Jones, Harrison, Ghia, Emanuela M., Rassenti, Laura Z., Kipps, Thomas J., Burkart, Michael D., Castro, Januario E.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486229/
https://ncbi.nlm.nih.gov/pubmed/25862704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.122069
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