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Daedal Facets of Splice Modulator Optimization

[Image: see text] The spliceosome has been shown to be a promising target for the development of new anticancer therapeutics. Synthetic and chemical biological efforts directed toward the development of natural product-based splice modulators (SPLMs) have shown that the potency of these compounds de...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Chan, Warren C., León, Brian, Krug, Kelsey A., Patel, Ashay, La Clair, James J., Burkart, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231189/
https://ncbi.nlm.nih.gov/pubmed/30429946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00456
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