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Trapping the complex molecular machinery of polyketide and fatty acid synthases with tunable silylcyanohydrin crosslinkers

Many families of natural products are synthesized by large multidomain biological machines commonly referred to as megasynthases. While the advance of mechanism-based tools has opened new windows into the structural features within the protein • protein interfaces guiding carrier protein dependent e...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Konno, Sho, La Clair, James J., Burkart, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407627/
https://ncbi.nlm.nih.gov/pubmed/30379389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201806865
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