The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells

Tie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor. Yet, Tie1 deletion is embryonic lethal and Tie1 has been implicated in critical vascular pathologies, including atherosclerosis and tumor angiogenesis. Here, we show that Tie1 does not function independent...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Savant, Soniya, Porta, Silvia La, Budnik, Annika, Busch, Katrin, Hu, Junhao, Tisch, Nathalie, Korn, Claudia, Valls, Aida Freire, Benest, Andrew V., Terhardt, Dorothee, Qu, Xianghu, Adams, Ralf H., Baldwin, H. Scott, de Almodó var, Carmen Ruiz, Rodewald, Hans-Reimer, Augustin, Hellmut G.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309948/
https://ncbi.nlm.nih.gov/pubmed/26344773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.024
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