Endothelial Tie1–mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis

The endothelial tyrosine kinase receptor Tie1 remains poorly characterized, largely owing to its orphan receptor status. Global Tie1 inactivation causes late embryonic lethality, thereby reflecting its importance during development. Tie1 also plays pivotal roles during pathologies such as atheroscle...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: La Porta, Silvia, Roth, Lise, Singhal, Mahak, Mogler, Carolin, Spegg, Carleen, Schieb, Benjamin, Qu, Xianghu, Adams, Ralf H., Baldwin, H. Scott, Savant, Soniya, Augustin, Hellmut G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785248/
https://ncbi.nlm.nih.gov/pubmed/29355844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94674
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