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Tie2 regulates endocardial sprouting and myocardial trabeculation
The ang1-tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) pathway is required for normal vascular development, but its molecular effectors are not well-defined during cardiac ontogeny. Here, we show that endocardial-specific attenuation of Tie2 results in midgestation lethality...
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| Udgivet i: | JCI Insight |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6629240/ https://ncbi.nlm.nih.gov/pubmed/31112136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96002 |
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