Endothelial Tie1–mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis

The endothelial tyrosine kinase receptor Tie1 remains poorly characterized, largely owing to its orphan receptor status. Global Tie1 inactivation causes late embryonic lethality, thereby reflecting its importance during development. Tie1 also plays pivotal roles during pathologies such as atheroscle...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: La Porta, Silvia, Roth, Lise, Singhal, Mahak, Mogler, Carolin, Spegg, Carleen, Schieb, Benjamin, Qu, Xianghu, Adams, Ralf H., Baldwin, H. Scott, Savant, Soniya, Augustin, Hellmut G.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785248/
https://ncbi.nlm.nih.gov/pubmed/29355844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94674
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