Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody

The angiopoietin (Ang)–Tie pathway has been intensely pursued as candidate second‐generation anti‐angiogenic target. While much of the translational work has focused on the ligand Ang2, the clinical efficacy of Ang2‐targeting drugs is limited and failed to improve patient survival. In turn, the orph...

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Publicado en:EMBO Mol Med
Main Authors: Singhal, Mahak, Gengenbacher, Nicolas, La Porta, Silvia, Gehrs, Stephanie, Shi, Jingjing, Kamiyama, Miki, Bodenmiller, Diane M, Fischl, Anthony, Schieb, Benjamin, Besemfelder, Eva, Chintharlapalli, Sudhakar, Augustin, Hellmut G
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7278563/
https://ncbi.nlm.nih.gov/pubmed/32302470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911164
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