Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and acts as a negative regulator of ANG-1/TIE2 signaling during angiogenesis, thereby controlling the responsiveness of ECs t...

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Main Authors: Felcht, Moritz, Luck, Robert, Schering, Alexander, Seidel, Philipp, Srivastava, Kshitij, Hu, Junhao, Bartol, Arne, Kienast, Yvonne, Vettel, Christiane, Loos, Elias K., Kutschera, Simone, Bartels, Susanne, Appak, Sila, Besemfelder, Eva, Terhardt, Dorothee, Chavakis, Emmanouil, Wieland, Thomas, Klein, Christian, Thomas, Markus, Uemura, Akiyoshi, Goerdt, Sergij, Augustin, Hellmut G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366398/
https://ncbi.nlm.nih.gov/pubmed/22585576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58832
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