Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

The angiopoietins (Ang-1 and Ang-2) have been identified as agonistic and antagonistic ligands of the endothelial receptor tyrosine kinase Tie2, respectively. Both ligands have been demonstrated to induce translocation of Tie2 to cell-cell junctions. However, only Ang-1 induces Tie2-dependent Akt ac...

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Detalhes bibliográficos
Main Authors: Thomas, Markus, Felcht, Moritz, Kruse, Karoline, Kretschmer, Stella, Deppermann, Carleen, Biesdorf, Andreas, Rohr, Karl, Benest, Andrew V., Fiedler, Ulrike, Augustin, Hellmut G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911308/
https://ncbi.nlm.nih.gov/pubmed/20519501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.097543
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