Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth

The angiopoietin/Tie2 system has been identified as the second vascular-specific receptor tyrosine kinase system controlling vessel assembly, maturation, and quiescence. Angiopoietin-2 (Ang-2) is prominently up-regulated in the host-derived vasculature of most tumors, making it an attractive candida...

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Detalhes bibliográficos
Main Authors: Nasarre, Patrick, Thomas, Markus, Kruse, Karoline, Helfrich, Iris, Wolter, Vivien, Deppermann, Carleen, Schadendorf, Dirk, Thurston, Gavin, Fiedler, Ulrike, Augustin, Hellmut G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514474/
https://ncbi.nlm.nih.gov/pubmed/19208839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3030
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