Sialic acid is a critical fetal defense against maternal complement attack

The negatively charged sugar sialic acid (Sia) occupies the outermost position in the bulk of cell surface glycans. Lack of sialylated glycans due to genetic ablation of the Sia-activating enzyme CMP–sialic acid synthase (CMAS) resulted in embryonic lethality around day 9.5 post coitum (E9.5) in mic...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Abeln, Markus, Albers, Iris, Peters-Bernard, Ulrike, Flächsig-Schulz, Kerstin, Kats, Elina, Kispert, Andreas, Tomlinson, Stephen, Gerardy-Schahn, Rita, Münster-Kühnel, Anja, Weinhold, Birgit
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307973/
https://ncbi.nlm.nih.gov/pubmed/30382946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99945
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