Sialic acid is a critical fetal defense against maternal complement attack

The negatively charged sugar sialic acid (Sia) occupies the outermost position in the bulk of cell surface glycans. Lack of sialylated glycans due to genetic ablation of the Sia-activating enzyme CMP–sialic acid synthase (CMAS) resulted in embryonic lethality around day 9.5 post coitum (E9.5) in mic...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Abeln, Markus, Albers, Iris, Peters-Bernard, Ulrike, Flächsig-Schulz, Kerstin, Kats, Elina, Kispert, Andreas, Tomlinson, Stephen, Gerardy-Schahn, Rita, Münster-Kühnel, Anja, Weinhold, Birgit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307973/
https://ncbi.nlm.nih.gov/pubmed/30382946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99945
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