Hepatocyte-Derived Lipotoxic Extracellular Vesicle Sphingosine 1-Phosphate Induces Macrophage Chemotaxis

Background: The pathophysiology of non-alcoholic steatohepatitis involves hepatocyte lipotoxicity due to excess saturated free fatty acids and concomitant proinflammatory macrophage effector responses. These include the infiltration of macrophages into hepatic cords in response to incompletely under...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Liao, Chieh-Yu, Song, Myeong Jun, Gao, Yandong, Mauer, Amy S., Revzin, Alexander, Malhi, Harmeet
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305739/
https://ncbi.nlm.nih.gov/pubmed/30619336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02980
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