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Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner

Nonalcoholic steatohepatitis (NASH) is a lipotoxic disease wherein activation of endoplasmic reticulum (ER) stress response and macrophage-mediated hepatic inflammation are key pathogenic features. However, the lipid mediators linking these two observations remain elusive. We postulated that ER stre...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Kakazu, Eiji, Mauer, Amy S., Yin, Meng, Malhi, Harmeet
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727419/
https://ncbi.nlm.nih.gov/pubmed/26621917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M063412
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