Lipid-induced Signaling Causes Release of Inflammatory Extracellular Vesicles from Hepatocytes

BACKGROUND & AIMS: Hepatocyte cellular dysfunction and death induced by lipids, and macrophage-associated inflammation are characteristics of nonalcoholic steatohepatitis (NASH). The fatty acid palmitate can activate death receptor 5 (DR5) on hepatocytes, leading to their death, but little is kn...

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Veröffentlicht in:Gastroenterology
Hauptverfasser: Hirsova, Petra, Ibrahim, Samar H., Krishnan, Anuradha, Verma, Vikas K., Bronk, Steven F., Werneburg, Nathan W., Charlton, Michael R., Shah, Vijay H., Malhi, Harmeet, Gores, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808464/
https://ncbi.nlm.nih.gov/pubmed/26764184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.12.037
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