Mixed Lineage Kinase 3 Mediates Release of C-X-C Motif Ligand 10-Bearing Chemotactic Extracellular Vesicles from Lipotoxic Hepatocytes

BACKGROUND AND AIMS: Mixed lineage kinase 3 (MLK3) deficiency reduces macrophage associated-inflammation in a murine model of nonalcoholic steatohepatitis (NASH). However, the mechanistic links between MLK3 activation in hepatocytes and macrophage-driven inflammation in NASH are uncharted. Herein, w...

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Détails bibliographiques
Publié dans:Hepatology
Auteurs principaux: Ibrahim, Samar H., Hirsova, Petra, Tomita, Kyoko, Bronk, Steven F., Werneburg, Nathan W., Harrison, Stephen A., Goodfellow, Val S., Malhi, Harmeet, Gores, Gregory J.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764421/
https://ncbi.nlm.nih.gov/pubmed/26406121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28252
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