Alcohol stimulates macrophage activation through caspase dependent hepatocyte derived release of CD40L containing extracellular vesicles

BACKGROUND/AIMS: The mechanisms by which hepatocyte exposure to alcohol activates inflammatory cells such as macrophages in alcoholic liver disease (ALD) are unclear. The role of released nano-sized membrane vesicles, termed extracellular vesicles (EV), in cell-to-cell communication has become incre...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: Verma, Vikas K., Li, Haiyang, Wang, Ruisi, Hirsova, Petra, Mushref, Malek, Liu, Yaming, Cao, Sheng, Contreras, Patricia C., Malhi, Harmeet, Kamath, Patrick S., Gores, Gregory J., Shah, Vijay H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761285/
https://ncbi.nlm.nih.gov/pubmed/26632633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.11.020
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