Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death

Interleukin-22 (IL-22) is a Th17 cell hepatoprotective cytokine that is undergoing clinical trials to treat patients with alcoholic hepatitis (AH). Lipopolysaccharide (LPS) activation of macrophage is implicated in hepatocyte cell death and pathogenesis of AH. The role of IL-22 production from macro...

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Bibliografiska uppgifter
I publikationen:Am J Physiol Cell Physiol
Huvudupphovsmän: Liu, Yaming, Verma, Vikas K., Malhi, Harmeet, Gores, Greg J., Kamath, Patrick S., Sanyal, Arun, Chalasani, Naga, Gao, Bin, Shah, Vijay H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625090/
https://ncbi.nlm.nih.gov/pubmed/28637673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00005.2017
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