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Novel screen for anti-cancer drugs that elevate chromosome instability (CIN) using human artificial chromosome (HAC)

Human artificial chromosomes (HACs) bearing functional kinetochores have been exploited as promising systems for gene delivery and expression and in studies of different epigenetic modifications on kinetochore structure and function. The HAC-based technology has been also used to develop drug screen...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Kouprina, Natalay, Pommier, Yves, Larionov, Vladimir
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305142/
https://ncbi.nlm.nih.gov/pubmed/30627324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26406
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