Impaired immune surveillance accelerates accumulation of senescent cells and aging

Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, preventing their propagation in tissues. However, senescent cells accumulate in tissues in advanced age, where they might promote tissue degeneration and malignant transformation. The extent of immune-sy...

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Опубликовано в: :Nat Commun
Главные авторы: Ovadya, Yossi, Landsberger, Tomer, Leins, Hanna, Vadai, Ezra, Gal, Hilah, Biran, Anat, Yosef, Reut, Sagiv, Adi, Agrawal, Amit, Shapira, Alon, Windheim, Joseph, Tsoory, Michael, Schirmbeck, Reinhold, Amit, Ido, Geiger, Hartmut, Krizhanovsky, Valery
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303397/
https://ncbi.nlm.nih.gov/pubmed/30575733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07825-3
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