Impaired immune surveillance accelerates accumulation of senescent cells and aging

Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, preventing their propagation in tissues. However, senescent cells accumulate in tissues in advanced age, where they might promote tissue degeneration and malignant transformation. The extent of immune-sy...

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Publicado no:Nat Commun
Main Authors: Ovadya, Yossi, Landsberger, Tomer, Leins, Hanna, Vadai, Ezra, Gal, Hilah, Biran, Anat, Yosef, Reut, Sagiv, Adi, Agrawal, Amit, Shapira, Alon, Windheim, Joseph, Tsoory, Michael, Schirmbeck, Reinhold, Amit, Ido, Geiger, Hartmut, Krizhanovsky, Valery
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303397/
https://ncbi.nlm.nih.gov/pubmed/30575733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07825-3
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