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p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling

Cellular senescence is a permanent state of cell cycle arrest that protects the organism from tumorigenesis and regulates tissue integrity upon damage and during tissue remodeling. However, accumulation of senescent cells in tissues during aging contributes to age‐related pathologies. A deeper under...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Yosef, Reut, Pilpel, Noam, Papismadov, Nurit, Gal, Hilah, Ovadya, Yossi, Vadai, Ezra, Miller, Stav, Porat, Ziv, Ben‐Dor, Shifra, Krizhanovsky, Valery
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538795/
https://ncbi.nlm.nih.gov/pubmed/28607003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695553
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