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Ezh2 programs T(FH) differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
Ezh2 is an histone methyltransferase (HMT) that catalyzes H3K27me3 and functions in T(H)1, T(H)2, and Treg cells primarily via HMT activity. Here we show that Ezh2 ablation impairs T follicular helper (T(FH)) cell differentiation and activation of the T(FH) transcription program. In T(FH) cells, mos...
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| Опубликовано в: : | Nat Commun |
|---|---|
| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6303346/ https://ncbi.nlm.nih.gov/pubmed/30575739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07853-z |
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