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IL-7 signalling represses Bcl-6 and the T(FH) gene program
The transcriptional repressor Bcl-6 is linked to the development of both CD4(+) T follicular helper (T(FH)) and central memory T (T(CM)) cells. Here, we demonstrate that in response to decreased IL-2 signalling, T helper 1 (T(H)1) cells upregulate Bcl-6 and co-initiate T(FH)- and T(CM)-like gene pro...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4729877/ https://ncbi.nlm.nih.gov/pubmed/26743592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10285 |
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